Zinc finger CCCH domain-containing protein 15

Zinc finger CCCH domain-containing protein 15 (ZC3H15) is a 426-amino-acid protein that functions as a regulatory cofactor for DRG1, a GTPase involved in ribosomal RNA processing. It protects DRG1 from proteolytic degradation and stimulates its GTPase activity, likely through enhanced potassium ion binding (UniProt: Q8WU90).

ZC3H15 belongs to the zinc finger CCCH protein family, which typically participates in RNA metabolism and cellular stress responses. No primary disease associations are documented in UniProt for this protein.

In Alzheimer's disease brain tissue, ZC3H15 shows ambiguous directional changes across subcellular fractions. Analysis of post-mortem AD brain versus age-matched controls using TMT-labeled proteomics across four subcellular fractions (P2, P3, S2, S3) yielded a mean log2 fold-change of −0.27, indicating minimal overall change but variable regulation depending on cellular compartment (Chaparral AD proteomics). This ambiguous pattern suggests context-dependent involvement in AD pathology.