protein
Golgi resident protein GCP60
Gene
ACBD3
Organism
Homo sapiens(9606)
Length
528 aa
Mass
60,593 Da
ACBD3 (Golgi resident protein GCP60) is a 528-amino acid protein that plays a key role in maintaining Golgi architecture and regulating protein transport. It functions by interacting with giantin to stabilize Golgi structure and mediates trafficking between the endoplasmic reticulum and Golgi apparatus (UniProt: Q9H3P7). The protein also recruits and enhances the activity of PI4KB at the Golgi membrane, concentrating substrate availability for phosphorylation.
ACBD3 is localized to the Golgi apparatus, where it participates in steroid biosynthesis in testicular Leydig cells and supports intracellular membrane trafficking (UniProt: Q9H3P7). The protein has also been implicated in viral replication processes, functioning in aichi virus RNA synthesis through PI4KB recruitment.
In Alzheimer's disease, ACBD3 is upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.29 (Chaparral AD proteomics). This elevation was detected across one subcellular fraction in a TMT-labeled quantitative proteomics study examining four distinct cellular compartments, suggesting that altered Golgi organization or membrane trafficking may be associated with pathological processes in AD.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
+0.287
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.2869 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi (PubMed:11590181). Involved in hormone-induced steroid biosynthesis in testicular Leydig cells (By similarity). Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase (PubMed:27009356)
(Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites
Sources
Last updated 5/8/2026, 6:38:11 AM