Protein kinase C and casein kinase substrate in neurons protein 1

PACSIN1 (Protein kinase C and casein kinase substrate in neurons protein 1) is a cytoskeletal scaffolding protein that regulates microtubule and actin dynamics through interactions with MAPT, dynamin proteins (DNM1/2/3), and actin regulators (COBL, WASL) (UniProt: Q9BY11). It functions in synaptic vesicle endocytosis, neurite morphogenesis, and neurotransmission, binding membranes via its F-BAR domain to mediate membrane tubulation and regulate neurite formation and branching.

PACSIN1 is predominantly expressed in neuronal tissues and plays critical roles in synaptic plasticity and vesicle recycling, essential for sustained neurotransmission. No disease associations are documented in the UniProt record.

In Alzheimer's Disease, PACSIN1 is significantly down-regulated in post-mortem brain tissue compared to age-matched controls (mean log2FC −0.71) based on quantitative proteomics of subcellular fractions (Chaparral AD proteomics). This reduction may impair synaptic endocytosis, membrane dynamics, and cytoskeletal remodeling, processes critical for synaptic integrity in neurodegeneration.