Probable ATP-dependent RNA helicase DDX23

DDX23 is a probable ATP-dependent RNA helicase that functions in pre-mRNA splicing and transcriptional regulation. When phosphorylated by SRPK2, it promotes spliceosomal B complex formation; independently, it suppresses aberrant R-loop formation during transcription by preventing DNA:RNA hybrids and associated single-stranded DNA accumulation (UniProt: Q9BUQ8).

The protein is expressed across multiple subcellular compartments and participates in fundamental splicing and transcriptional processes relevant to neuronal function, though no specific disease associations are documented in UniProt.

DDX23 has been identified as relevant to Alzheimer's Disease through proteomics analysis. In a human post-mortem AD brain study comparing affected tissue to age-matched controls using TMT-labeled, four-fraction subcellular proteomics (Chaparral AD proteomics), DDX23 showed ambiguous directional change across fractions with a mean log2 fold-change of −0.16, suggesting minimal net change or inconsistent regulation across subcellular compartments in AD pathology.