Isoform 1 of A-kinase anchor protein 9

AKAP9 (A-kinase anchor protein 9) is a large scaffolding protein that functions as an anchoring platform for protein kinase A (PKA) signaling complexes (UniProt: Q99996-1). Scaffolding proteins like AKAP9 coordinate cellular signaling by localizing kinases and their substrates in specific cellular compartments. This protein is expressed in human tissues and participates in the organization of signaling cascades critical for diverse cellular processes.

AKAP9 has been identified in post-mortem human brain tissue from Alzheimer's Disease patients compared to age-matched controls using TMT-labeled proteomics across multiple subcellular fractions (Chaparral AD proteomics). The protein is consistently down-regulated in AD brain tissue, with a mean log2 fold-change of −0.51, suggesting reduced expression or abundance in the disease state. This down-regulation may reflect altered PKA signaling capacity or disrupted cellular organization in AD pathology. No additional curated disease associations were found in the UniProt record for this entity.