protein
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha
Gene
AGPAT1
Organism
Homo sapiens(9606)
Length
283 aa
Mass
31,717 Da
AGPAT1 (1-acyl-sn-glycerol-3-phosphate acyltransferase alpha) catalyzes the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a critical step in phospholipid biosynthesis (UniProt: Q99943). This enzyme incorporates an acyl moiety at the sn-2 position of the glycerol backbone, thereby regulating membrane lipid composition and cellular signaling downstream of PA-responsive pathways.
AGPAT1 is implicated in lipid metabolism across multiple tissues and cell types. While no disease associations are documented in the primary UniProt record, the enzyme's role in membrane biogenesis and remodeling suggests relevance to neurodegenerative processes where lipid homeostasis is disrupted.
AGPAT1 is downregulated in Alzheimer's Disease brain tissue. Proteomics analysis of post-mortem AD brain compared to age-matched controls revealed a mean log₂ fold-change of −0.35 (Chaparral AD proteomics), suggesting reduced PA synthesis capacity in the disease state. This downregulation may reflect impaired phospholipid remodeling and membrane integrity in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.353
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3529 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone
Sources
Last updated 5/8/2026, 6:36:06 AM