protein
Necdin
Gene
NDN
Organism
Homo sapiens(9606)
Length
321 aa
Mass
36,086 Da
Necdin (NDN) is a 321-amino acid protein classified as a growth suppressor that regulates cell cycle progression (UniProt: Q99608). It functions by binding to and repressing cell-cycle-promoting proteins including SV40 large T antigen, adenovirus E1A, and the transcription factor E2F, similar to retinoblastoma protein. Necdin also interacts with p53 and cooperates additively to inhibit cell growth, and acts as a transcription factor by directly binding guanosine-rich DNA sequences.
Necdin is associated with Prader-Willi syndrome through its genomic location in the imprinted PWS region on chromosome 15. The protein's role in cell cycle control and growth regulation positions it within pathways governing cellular proliferation and differentiation in developing tissues.
Necdin is classified as a syndromic autism-associated gene (SFARI Cat S), indicating a curated association with autism spectrum disorder, particularly in the context of Prader-Willi syndrome where neurodevelopmental features are characteristic (SFARI Cat S). Its involvement in cell cycle regulation suggests potential relevance to neurodevelopmental processes, though the specific mechanistic contribution to autism pathogenesis remains to be fully elucidated.
Generated from the curated entity record below. May contain errors — verify against source links.
Genetic Evidence · ASD
Source: SFARI Gene database · gene.sfari.org
Related Publications
Browse all →Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.
Ruzzo Elizabeth K et al.Cell2019PMID 31398340Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model.
Guo Hui et al.Molecular autism2018PMID 30564305Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.
C Yuen Ryan K et al.Nature neuroscience2017PMID 28263302Identification of common genetic risk variants for autism spectrum disorder.
Grove Jakob et al.Nature genetics2019PMID 30804558Synaptic, transcriptional and chromatin genes disrupted in autism.
De Rubeis Silvia et al.Nature2014PMID 25363760
Function
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity)
Sources
Last updated 5/6/2026, 5:24:18 AM