Regulator of microtubule dynamics protein 3

Regulator of microtubule dynamics protein 3 (RMDN3) is a 470-amino acid protein involved in cellular calcium homeostasis regulation (UniProt: Q96TC7). The protein may participate in keratinocyte differentiation and apoptosis, with overexpression known to induce programmed cell death.

RMDN3 localizes to multiple subcellular compartments and is expressed in human tissues. No Mendelian disease associations are currently documented in UniProt records for this protein.

In Alzheimer's Disease, RMDN3 is downregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.37 (Chaparral AD proteomics). This reduction was observed across subcellular fractions in TMT-labeled quantitative proteomics analysis, suggesting potential involvement in calcium dysregulation or apoptotic pathway alterations associated with AD pathology.