protein
Apoptosis-inducing factor 3
Gene
AIFM3
Organism
Homo sapiens(9606)
Length
605 aa
Mass
66,791 Da
AIFM3 (apoptosis-inducing factor 3) is a 605-amino acid mitochondrial protein that promotes programmed cell death through caspase-dependent apoptotic pathways and dissipation of the mitochondrial membrane potential (UniProt: Q96NN9). The protein localizes to mitochondria where it functions as a pro-apoptotic regulator, linking cellular stress responses to mitochondrial dysfunction.
AIFM3 has no annotated disease associations in UniProt. Its cellular role in mitochondrial-mediated apoptosis situates it within broader pathways governing neuronal survival and death, which are relevant to neurodegenerative processes.
In Alzheimer's disease, AIFM3 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of +0.49 (Chaparral AD proteomics). This increase was detected across subcellular fractions in TMT-labeled quantitative proteomic analysis, suggesting enhanced apoptotic signaling in AD pathology and potential contribution to neuronal loss characteristic of the disease.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
not detected
S2
+0.485
S3
not detected
Mean log₂FC across detected fractions: +0.4854 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential
Sources
Last updated 5/8/2026, 6:35:49 AM