protein
Anaphase-promoting complex subunit 16
aka APC16
Gene
ANAPC16
Organism
Homo sapiens(9606)
Length
110 aa
Mass
11,667 Da
ANAPC16 encodes anaphase-promoting complex subunit 16 (APC16), a small regulatory component of the anaphase-promoting complex/cyclosome (APC/C). The APC/C is a cell cycle-regulated E3 ubiquitin ligase that controls mitotic progression and G1 phase transition by catalyzing ubiquitination and proteasomal degradation of cell cycle regulators, primarily through formation of Lys-11-linked polyubiquitin chains (UniProt: Q96DE5).
APC16 functions as part of a multisubunit machinery essential for proper cell cycle control. The broader APC/C complex is active in all proliferating cells and plays a critical role in maintaining genomic stability through regulated protein degradation during cell division (UniProt: Q96DE5).
In Alzheimer's disease, ANAPC16 is downregulated in post-mortem AD brain tissue compared to age-matched controls (mean log2 fold-change: −0.38) as assessed by TMT-labeled proteomics across multiple subcellular fractions (Chaparral AD proteomics). This reduction may reflect altered cell cycle regulation or diminished proteasomal clearance capacity in AD brain, though the functional consequences of ANAPC16 downregulation in neurodegeneration remain to be established.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.379
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3789 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:20360068). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132)
Sources
Last updated 5/8/2026, 6:33:48 AM