protein
Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Gene
ACSF2
Organism
Homo sapiens(9606)
Length
615 aa
Mass
68,125 Da
ACSF2 is a mitochondrial medium-chain acyl-CoA ligase that catalyzes the initial step of fatty acid metabolism by forming a thioester with CoA (UniProt: Q96CM8). The enzyme shows preference for medium-chain substrates and is known to participate in adipocyte differentiation.
ACSF2 is localized to mitochondria and functions in the fatty acid β-oxidation pathway, which is central to cellular energy metabolism (UniProt: Q96CM8). No disease associations are documented in UniProt's curated disease field.
ACSF2 is elevated in Alzheimer's Disease brain tissue. Analysis of post-mortem AD brain compared to age-matched controls by quantitative proteomics (TMT-labeled, DDA mass spectrometry across four subcellular fractions) showed ACSF2 upregulation with a mean log2 fold-change of 0.44 (Chaparral AD proteomics). This increase may reflect altered lipid metabolism in AD pathology, though the biological significance requires further investigation.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
+0.443
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.4425 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA (PubMed:17762044). Has some preference toward medium-chain substrates (PubMed:17762044). Plays a role in adipocyte differentiation (PubMed:16380219)
Sources
Last updated 5/8/2026, 6:38:01 AM