Lipoma-preferred partner

Lipoma-preferred partner (LPP) is a 612-amino acid cytoplasmic and nuclear scaffold protein that mediates cell adhesion and signal transduction. It maintains cell shape and motility through structural functions at adhesion sites while simultaneously facilitating signaling between the cell surface and nucleus, allowing integration of signals from soluble factors and cell-cell interactions (UniProt: Q93052). LPP serves as a platform for assembling distinct protein complexes in both cytoplasmic and nuclear compartments, implicating it in coordinating adhesion-dependent gene transcription.

LPP shows elevated expression in Alzheimer's disease brain tissue. In a differential proteomic analysis of post-mortem AD brain versus age-matched controls using tandem mass tag labeling across four subcellular fractions, LPP was significantly upregulated with a mean log2 fold-change of 0.62 (Chaparral AD proteomics). This upregulation suggests altered adhesive or signaling functions may contribute to AD pathology, though the specific cellular context of this change warrants further investigation.