LIM and SH3 domain protein 1

LASP1 (LIM and SH3 domain protein 1) is a 29.7 kDa cytoskeletal regulatory protein that plays an important role in controlling dynamic actin-based cytoskeletal activities (UniProt: Q14847). The protein regulates agonist-dependent phosphorylation changes that modulate actin-associated ion transport, particularly in F-actin-rich secretory epithelial cells. Its molecular functions center on actin dynamics and cellular structural organization (UniProt: Q14847).

LASP1 is expressed in tissues with prominent cytoskeletal requirements and has not been previously associated with genetic disease in the UniProt record (UniProt: Q14847). The protein participates in cellular processes fundamental to polarized secretion and ion transport activities across epithelial barriers.

In Alzheimer's disease, LASP1 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 1.01 (Chaparral AD proteomics). This upregulation was detected in TMT-labeled mass spectrometry analysis of subcellular fractions from human AD brain samples, suggesting altered cytoskeletal dynamics may represent a pathophysiological feature of AD neurodegeneration.