Isoform 4 of Atlastin-2

Atlastin-2 (ATL2) is a dynamin-related GTPase isoform involved in membrane fusion and endoplasmic reticulum (ER) morphology. The ATL family functions in homotypic ER membrane tethering and fusion, contributing to ER network formation and maintenance (UniProt: Q8NHH9-4).

ATL2 is widely expressed across tissues and plays roles in ER dynamics and vesicular transport. No additional disease associations are documented in UniProt records for this isoform.

This isoform shows down-regulation in Alzheimer's Disease, with a mean log2 fold-change of −0.26 in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The measurement derives from a single subcellular fraction in a TMT-labeled, data-dependent acquisition proteomics study examining four fractions (P2, P3, S2, S3) from human brain samples. The modest magnitude of change and limited fraction coverage warrant caution in interpreting functional significance.