Late secretory pathway protein AVL9 homolog

AVL9 (Late secretory pathway protein AVL9 homolog) is a 71.9 kDa protein involved in cell migration (UniProt: Q8NBF6). Its role in the secretory pathway suggests involvement in protein trafficking and cellular transport processes, though its specific molecular mechanisms remain incompletely characterized in the UniProt record.

AVL9 is expressed in human tissues and localizes to the late secretory pathway. The UniProt record lists no annotated disease associations, though the protein's function in cell migration indicates potential relevance to processes requiring cytoskeletal dynamics and cellular motility.

AVL9 is down-regulated in Alzheimer's Disease brain tissue. Proteomic analysis of post-mortem AD brain versus age-matched controls revealed a mean log2 fold-change of −0.963 across one subcellular fraction (Chaparral AD proteomics). This reduction in AVL9 levels suggests potential involvement in AD-related pathophysiology, though the functional consequences and mechanistic basis of this down-regulation require further investigation.