Ankyrin repeat domain-containing protein 29

# ANKRD29 (Ankyrin Repeat Domain-Containing Protein 29)

ANKRD29 is a 301-amino acid protein encoded by the ANKRD29 gene in humans (UniProt: Q8N6D5). The protein contains ankyrin repeat domains, which are modular protein-interaction motifs commonly involved in regulatory and structural functions. Detailed molecular function annotations are not currently available in UniProt, though ankyrin repeats typically mediate protein–protein interactions in signal transduction and cellular organization.

Tissue-specific expression patterns and pathway assignments are not documented in the available UniProt record. No disease associations have been curated in the UniProt entry itself.

ANKRD29 is relevant to Alzheimer's Disease: it is upregulated in post-mortem AD brain tissue compared to age-matched controls in a TMT-labeled proteomics study across multiple subcellular fractions (P2, P3, S2, S3) (Chaparral AD proteomics). The protein shows a mean log2 fold-change of 0.43, indicating modest elevation. This upregulation may reflect changes in cellular architecture or protein interaction networks associated with neurodegeneration.