Isoform 3 of Inactive dipeptidyl peptidase 10

Inactive dipeptidyl peptidase 10 (DPP10) is a serine protease family member annotated as catalytically inactive (UniProt: Q8N608-3). The protein is 800 amino acids in length and exists in multiple isoforms. While the precise molecular interactions of this inactive form remain to be fully characterized, DPP10 is structurally related to active dipeptidyl peptidases, which typically function in peptide metabolism and immune regulation across various tissues.

DPP10 is expressed in human tissues with potential roles in protease-related pathways. The UniProt record does not document specific tissue localization or pathway associations for this isoform (UniProt: Q8N608-3). No UniProt-curated disease associations are currently annotated for this protein.

In Alzheimer's Disease, DPP10 isoform 3 is significantly down-regulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics; mean log2 fold-change: −0.462). This reduction was detected across the analyzed subcellular fractions in a TMT-labeled proteomic study. The functional relevance of decreased DPP10 levels in AD pathology warrants further investigation.