Amphiphysin

Amphiphysin (AMPH, UniProt: P49418) is a 695-amino acid protein that participates in regulated exocytosis at synapses and in certain endocrine cells, and may regulate membrane-associated cytoskeletal properties (UniProt: P49418). The protein is expressed in neural tissue where it functions in synaptic transmission and vesicle dynamics. No diseases are listed in the UniProt record for this protein.

Amphiphysin is relevant to Alzheimer's Disease pathology. In human post-mortem AD brain tissue compared to age-matched controls, amphiphysin was upregulated with a mean log2 fold-change of +0.544 across one subcellular fraction in a four-fraction TMT-labeled differential proteomics study (Chaparral AD proteomics). The upregulation suggests potential compensatory changes or altered synaptic dynamics in AD-affected brain regions, though the modest effect size and single-fraction result warrant validation across additional subcellular compartments.