Isoform 2 of Armadillo repeat-containing protein 10

Armadillo repeat-containing protein 10 (ARMC10) isoform 2 is a 308-amino acid protein encoded by the ARMC10 gene in humans (UniProt: Q8N2F6-2). The protein contains armadillo repeats, a structural motif typically involved in protein-protein interactions and cellular signaling. Specific molecular functions and tissue distribution details are not currently annotated in UniProt for this isoform.

ARMC10 isoform 2 shows reduced abundance in Alzheimer's Disease brain tissue. In post-mortem AD brain compared to age-matched controls, this protein was down-regulated with a mean log2 fold-change of −0.35 across subcellular fractions analyzed by tandem mass tag proteomics (Chaparral AD proteomics). The protein was detected in one of four examined subcellular fractions (P2, P3, S2, S3), indicating compartment-specific localization or stability changes associated with AD pathology.

The biological significance of ARMC10 isoform 2 down-regulation in AD remains to be elucidated, though the consistent reduction suggests potential involvement in disease-related cellular dysfunction or protein interaction networks altered in neurodegeneration.