Armadillo repeat-containing protein 10

ARMC10 (Armadillo repeat-containing protein 10) is a 343-amino acid protein that may suppress the transcriptional activity of p53/TP53 and play a role in cell survival and cell growth (UniProt: Q8N2F6). The protein's specific tissue distribution and pathway context have not been extensively characterized in available databases.

ARMC10 shows reduced abundance in Alzheimer's Disease brain tissue. According to Chaparral AD proteomics analysis of post-mortem AD brain compared to age-matched controls, ARMC10 is downregulated with a mean log2 fold-change of −0.41 across subcellular fractions in a TMT-labeled quantitative proteomics experiment. This modest downregulation was detected in the analysis of four subcellular fractions (P2, P3, S2, S3) using data-dependent acquisition mass spectrometry. The biological significance of reduced ARMC10 levels in AD pathology remains to be determined, though its reported role in p53 suppression suggests potential relevance to cellular stress responses implicated in neurodegeneration.