Isoform 10 of Ankyrin repeat and sterile alpha motif domain-containing protein 1B

ANKS1B encodes an ankyrin repeat and sterile alpha motif domain-containing protein; isoform 10 is a 394-amino acid variant (UniProt: Q7Z6G8-10). The ankyrin repeat and SAM domain architecture suggests roles in protein-protein interactions and potential signaling functions, though specific molecular targets are not annotated in UniProt for this isoform.

The protein is expressed in human brain tissue and has been evaluated in the context of Alzheimer's Disease pathology. No UniProt disease associations are currently documented for ANKS1B (UniProt: Q7Z6G8-10).

In Alzheimer's Disease, ANKS1B isoform 10 is significantly downregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.44 across subcellular fractions in TMT-labeled quantitative proteomics (Chaparral AD proteomics). This consistent downregulation across the analyzed brain fractions suggests potential involvement in pathways disrupted during AD neurodegeneration.