protein
Alpha/beta hydrolase domain-containing protein 17C
aka Abhydrolase domain-containing protein 17C
Gene
ABHD17C
Organism
Homo sapiens(9606)
Length
329 aa
Mass
35,831 Da
ABHD17C is an alpha/beta hydrolase domain-containing protein that catalyzes the removal of fatty acids from S-acylated cysteine residues in proteins, with demonstrated depalmitoylating activity toward NRAS and DLG4/PSD95 (UniProt: Q6PCB6). This deacylation function positions the protein at the interface of post-translational lipid modification and protein trafficking regulation.
The protein is expressed in human tissues and participates in the dynamic regulation of protein S-acylation, a modification critical for membrane targeting and synaptic protein localization. No UniProt-curated disease associations are currently documented for ABHD17C.
In Alzheimer's Disease, ABHD17C is significantly downregulated in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is −0.31 across analyzed subcellular fractions from TMT-labeled human brain samples. This reduced expression may impair depalmitoylation capacity, potentially affecting the trafficking and function of key synaptic proteins implicated in neurodegeneration.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
not detected
S3
-0.308
Mean log₂FC across detected fractions: -0.3076 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95
Sources
Last updated 5/8/2026, 6:38:57 AM