Adenylyl cyclase-associated protein 1

Adenylyl cyclase-associated protein 1 (CAP1) is a cytoplasmic regulator of actin filament dynamics that plays roles in mRNA localization and cell polarity establishment (UniProt: Q01518). The protein functions in broader developmental and morphological processes across multiple cell types and tissues.

CAP1 has no disease associations documented in UniProt's curated records. However, it has been identified as relevant to Alzheimer's Disease through proteomic analysis of post-mortem human brain tissue.

In Alzheimer's Disease, CAP1 is significantly up-regulated in the AD brain compared to age-matched controls, with a mean log2 fold-change of 0.28 across subcellular fractions (Chaparral AD proteomics). This elevation was detected via quantitative mass spectrometry (TMT-labeled, DDA) in post-mortem tissue from multiple subcellular compartments (P2, P3, S2, S3 fractions), suggesting altered filament dynamics or cellular polarity signaling may contribute to AD pathobiology.