protein
Actin-binding LIM protein 2
aka abLIM-2
Gene
ABLIM2
Organism
Homo sapiens(9606)
Length
611 aa
Mass
67,812 Da
Actin-binding LIM protein 2 (ABLIM2) is a 611-amino-acid scaffold protein that may stimulate ABRA activity and enhance ABRA-dependent serum response factor (SRF) transcriptional activity (UniProt: Q6H8Q1). Its molecular function centers on actin binding and cytoskeletal regulation through protein-scaffold interactions.
ABLIM2 is expressed in human tissues with roles in actin dynamics and transcriptional signaling. No primary disease associations are reported in UniProt's curated disease database.
In Alzheimer's disease, ABLIM2 is downregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.59 measured by TMT-labeled quantitative proteomics across subcellular fractions (Chaparral AD proteomics). This downregulation suggests potential involvement in cytoskeletal or transcriptional disruptions associated with neurodegeneration, though the biological consequence remains to be determined.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
not detected
S2
-0.591
S3
not detected
Mean log₂FC across detected fractions: -0.5907 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
May act as scaffold protein. May stimulate ABRA activity and ABRA-dependent SRF transcriptional activity
Sources
Last updated 5/8/2026, 6:38:51 AM