protein
Rho GTPase-activating protein 17
Gene
ARHGAP17
Organism
Homo sapiens(9606)
Length
881 aa
Mass
95,437 Da
ARHGAP17 (Rho GTPase-activating protein 17) is a Rho family GTPase regulator that functions as a GTPase-activating protein for CDC42 and RAC1, converting them to inactive GDP-bound states (UniProt: Q68EM7). It plays a central role in maintaining epithelial tight junctions and apical polarity by regulating the uptake and trafficking of polarity proteins, and participates in calcium-dependent exocytosis through reorganization of cortical actin filaments.
ARHGAP17 is expressed in human tissues and operates within signaling pathways governing cell polarity and junction integrity. No disease associations are documented in the UniProt record, though the protein's role in cellular organization and membrane trafficking suggests broader biological significance in epithelial homeostasis.
In Alzheimer's Disease, ARHGAP17 shows elevated abundance in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of 0.29 across measured fractions. This upregulation may reflect compensatory mechanisms or disease-associated remodeling of cellular polarity and membrane dynamics in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.286
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.2857 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1
Sources
Last updated 5/8/2026, 6:30:42 AM