PDZ domain-containing protein 11

PDZ domain-containing protein 11 (PDZD11) is a small scaffolding protein that mediates the docking of ADAM10 to zonula adherens junctions through interaction with PLEKHA7, thereby facilitating ADAM10's engagement with its binding partner TSPAN33 (UniProt: Q5EBL8). This protein plays a role in organizing adhesion complexes and may influence signaling at cell–cell junctions.

PDZD11 is expressed in human tissues and functions within adherens junction and membrane protein trafficking pathways. No disease associations are documented in UniProt records for this protein.

PDZD11 is upregulated in Alzheimer's disease brain tissue. Analysis of post-mortem AD brain versus age-matched controls using quantitative proteomics detected a modest but consistent increase, with a mean log2 fold-change of +0.46 (Chaparral AD proteomics). This upregulation was observed across subcellular fractions in the TMT-based proteomic dataset, suggesting potential involvement in AD-related pathological processes, though the functional significance remains to be determined.