protein
V-type proton ATPase subunit F
aka V-ATPase subunit F
Gene
ATP6V1F
Organism
Homo sapiens(9606)
Length
119 aa
Mass
13,370 Da
ATP6V1F (V-type proton ATPase subunit F) is a 119-amino-acid subunit of the V1 complex of vacuolar proton-ATPase (V-ATPase), a multisubunit enzyme responsible for ATP hydrolysis and proton translocation (UniProt: Q16864). The protein is part of the peripheral V1 complex that drives acidification of intracellular compartments and, in certain cell types, the extracellular environment via the membrane-integrated V0 complex.
V-ATPase subunits are expressed across tissues where proton-dependent pH regulation is essential, including neurons and glial cells involved in synaptic vesicle acidification and autophagy. No disease associations are currently annotated in UniProt for ATP6V1F.
In Alzheimer's disease, ATP6V1F is downregulated in post-mortem AD brain tissue relative to age-matched controls (mean log2 fold-change −0.32; Chaparral AD proteomics). This finding derives from TMT-labeled mass spectrometry profiling across four subcellular fractions (P2, P3, S2, S3) in human post-mortem brain tissue. The mild reduction may reflect altered vesicular trafficking or autophagy-lysosomal dysfunction relevant to AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
-0.322
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3219 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity)
Sources
Last updated 5/8/2026, 6:26:36 AM