protein
Adipogenesis regulatory factor
Gene
ADIRF
Organism
Homo sapiens(9606)
Length
76 aa
Mass
7,855 Da
Adipogenesis regulatory factor (ADIRF) is a small 76-amino acid protein that promotes fat cell development by stimulating transcription of master adipogenesis regulators such as PPARG and CEBPA during preadipocyte differentiation (UniProt: Q15847). The protein has also been noted to confer resistance to the chemotherapeutic agent cisplatin when overexpressed. Its primary known function centers on metabolic regulation during adipogenic lineage commitment.
UniProt records no direct disease associations for ADIRF in their curated database. However, tissue-level expression and metabolic regulatory roles suggest potential relevance to conditions involving lipid metabolism and cellular stress responses.
ADIRF shows upregulation in Alzheimer's disease brain tissue, with a mean log2-fold change of +0.784 across three subcellular fractions in post-mortem AD brain compared to age-matched controls (Chaparral AD proteomics). This upregulation was detected via TMT-labeled quantitative proteomics across four subcellular fractions, though the modest effect size and tissue-level measurement warrant further investigation to determine functional significance in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
+0.991
S2
+0.858
S3
+0.504
Mean log₂FC across detected fractions: +0.784 (3 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Plays a role in fat cell development; promotes adipogenic differentiation and stimulates transcription initiation of master adipogenesis factors like PPARG and CEBPA at early stages of preadipocyte differentiation. Its overexpression confers resistance to the anticancer chemotherapeutic drug cisplatin
Sources
Last updated 5/8/2026, 6:36:42 AM