Ras suppressor protein 1

Ras suppressor protein 1 (RSU1) is a 277-amino acid protein that potentially modulates the Ras signal transduction pathway and can suppress v-Ras-mediated transformation in vitro (UniProt: Q15404). The protein's precise cellular functions and tissue distribution remain incompletely characterized, though its involvement in Ras signaling suggests relevance to growth regulatory processes.

RSU1 shows elevated abundance in human post-mortem Alzheimer's disease brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.38 across subcellular fractions (Chaparral AD proteomics). This upregulation was detected via TMT-labeled quantitative proteomics across four subcellular compartments (P2, P3, S2, S3 fractions), indicating consistent dysregulation of this signaling-related protein in AD pathology. The modest but consistent increase suggests potential involvement in disease-associated changes in cellular signal transduction.