protein
ELAV-like protein 3
Gene
ELAVL3
Organism
Homo sapiens(9606)
Length
367 aa
Mass
39,547 Da
ELAVL3 (ELAV-like protein 3) is an RNA-binding protein that recognizes and binds AU-rich element (ARE) sequences within target messenger RNAs, including VEGF mRNA (UniProt: Q14576). The protein contains RNA recognition motifs and may also interact with poly-A tracts through its third RRM domain. Functionally, ELAVL3 is implicated in stabilizing specific mRNAs and regulating their expression.
ELAVL3 is involved in neuronal differentiation and maintenance processes, with particular roles in stabilizing GAP43 mRNA and supporting spatial learning capabilities (UniProt: Q14576). The protein functions within neuronal contexts where RNA regulation is essential for proper neural development and synaptic function. No disease associations are currently documented in the UniProt record.
This protein carries an SFARI category 2 classification (SFARI Cat 2), indicating suggestive evidence for autism spectrum disorder involvement. This tag reflects potential relevance to neurodevelopmental pathways, though specific mechanistic links to ASD require further investigation.
Generated from the curated entity record below. May contain errors — verify against source links.
Genetic Evidence · ASD
Strong candidate — functional studies support ASD association
Source: SFARI Gene database · gene.sfari.org
Related Publications
Browse all →Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.
Ruzzo Elizabeth K et al.Cell2019PMID 31398340Inherited and multiple de novo mutations in autism/developmental delay risk genes suggest a multifactorial model.
Guo Hui et al.Molecular autism2018PMID 30564305Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.
C Yuen Ryan K et al.Nature neuroscience2017PMID 28263302Identification of common genetic risk variants for autism spectrum disorder.
Grove Jakob et al.Nature genetics2019PMID 30804558Synaptic, transcriptional and chromatin genes disrupted in autism.
De Rubeis Silvia et al.Nature2014PMID 25363760
Function
RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity)
Sources
Last updated 5/6/2026, 5:24:10 AM