Isoform PTPS-F4-7 of Receptor-type tyrosine-protein phosphatase S

PTPRS (protein tyrosine phosphatase receptor type S) is a receptor-type tyrosine phosphatase involved in cell–cell communication and signal regulation (UniProt: Q13332-5). The encoded protein functions as a membrane-bound phosphatase that modulates receptor tyrosine kinase signaling. Isoform PTPS-F4-7 represents a specific N-terminal variant of this multi-domain phosphatase.

PTPRS is broadly expressed across tissues and participates in developmental and homeostatic signaling pathways. The UniProt record contains no curated disease associations for this protein (UniProt: Q13332-5).

In Alzheimer's Disease, this PTPRS isoform shows reduced abundance in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). The mean log2 fold-change is −0.40, indicating modest downregulation across the examined subcellular fractions. This decrease may reflect altered phosphatase signaling capacity in AD pathology, though the functional consequence remains to be determined.