Oligodendrocyte-myelin glycoprotein

Oligodendrocyte-myelin glycoprotein (OMG) is a cell adhesion molecule that contributes to myelination in the central nervous system by facilitating interactive processes required for myelin formation (UniProt: P23515). The protein is expressed in oligodendrocytes and plays a structural role in CNS myelin organization.

OMG has not been documented as associated with disease in the UniProt knowledgebase. However, proteomics profiling has identified it as dysregulated in Alzheimer's disease pathology.

OMG is downregulated in post-mortem Alzheimer's disease brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.37 across multiple subcellular fractions (Chaparral AD proteomics). This reduction may reflect loss of oligodendrocyte integrity or demyelination processes implicated in AD-related neurodegeneration, although the functional significance of this change requires further investigation.