Golgin subfamily A member 3

GOLGA3 (Golgin subfamily A member 3) is a Golgi auto-antigen protein that plays a structural role in maintaining Golgi apparatus integrity (UniProt: Q08378). The protein is a member of the golgin family and is implicated in Golgi organization and function through its association with the Golgi matrix.

In the context of Alzheimer's Disease, GOLGA3 shows a consistent downregulation pattern in post-mortem AD brain tissue. According to Chaparral AD proteomics analysis using TMT-labeled quantitative mass spectrometry across multiple subcellular fractions (P2, P3, S2, S3), GOLGA3 is significantly decreased with a mean log2 fold-change of −0.39 compared to age-matched controls. This reduction suggests potential impairment of Golgi function and protein trafficking in AD pathology.

The downregulation of structural golgin proteins may reflect broader disruption of the secretory pathway and protein homeostasis mechanisms characteristic of Alzheimer's neurodegeneration. The consistent directional change across the proteomics dataset indicates GOLGA3 as a potential biomarker of Golgi dysfunction in AD brain.