Serine/arginine-rich splicing factor 3

SRSF3 is a serine/arginine-rich splicing factor that regulates alternative splicing by binding specific RNA motifs within pre-mRNA and promoting selective exon inclusion (UniProt: P84103). The protein also functions as an adapter in mRNA nuclear export by facilitating binding to the NXF1-NXT1 export machinery. Additionally, SRSF3 interacts with YTHDC1 to promote recruitment and export of N6-methyladenosine (m6A)-containing mRNAs through the TAP/NXF1 pathway.

SRSF3 is widely expressed and involved in fundamental RNA processing and nucleocytoplasmic transport pathways. No tissue-specific or non-AD disease associations are documented in UniProt for this protein.

In Alzheimer's disease, SRSF3 is significantly upregulated in post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.40 across subcellular fractions (Chaparral AD proteomics). This elevation suggests potential involvement in altered splicing or mRNA export dysregulation associated with AD pathology.