ATP-dependent 6-phosphofructokinase, platelet type

ATP-dependent 6-phosphofructokinase, platelet type (PFKP) is a glycolytic enzyme that catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate, representing the first committed step of the glycolytic pathway (UniProt: Q01813). This 85.6 kDa protein is expressed across multiple tissue types and plays a central role in cellular energy metabolism.

PFKP is one of three phosphofructokinase isoforms in humans, with the platelet isoform showing tissue-specific expression patterns. The UniProt record contains no annotated disease associations for PFKP (UniProt: Q01813).

In Alzheimer's disease, PFKP shows decreased abundance in human post-mortem AD brain tissue compared to age-matched controls, with a mean log2 fold-change of −0.47 across subcellular fractions (Chaparral AD proteomics). This downregulation suggests potential impairment of glycolytic capacity in AD brain, consistent with broader metabolic dysregulation observed in neurodegeneration. The finding was obtained from TMT-labeled quantitative proteomics of four subcellular fractions in a discovery-driven analysis.