Summary

SLC25A3 (solute carrier family 25 member 3) encodes a member of the mitochondrial carrier protein family, which functions in the transport of phosphate and other metabolites across the inner mitochondrial membrane (UniProt: Q00325-2). These carriers are essential for cellular bioenergetics and metabolic homeostasis in tissues with high ATP demand.

The protein is expressed across tissues and plays a role in mitochondrial function and cellular energy metabolism. While no specific disease associations are documented in the UniProt record for SLC25A3, the protein is relevant to conditions involving mitochondrial dysfunction and metabolic perturbation.

SLC25A3 isoform B is upregulated in Alzheimer's disease brain tissue (Chaparral AD proteomics). In post-mortem AD brain samples compared to age-matched controls, the protein showed increased abundance with a mean log2 fold-change of +1.41 across one subcellular fraction in a TMT-labeled proteomics experiment spanning four fractions. This upregulation may reflect compensatory mitochondrial responses or altered energy metabolism in AD pathology.