Brain acid soluble protein 1

Brain acid soluble protein 1 (BASP1) is a small, 227-amino acid protein encoded by the BASP1 gene (UniProt: P80723). While specific molecular function annotations are not detailed in available curated databases, BASP1 is a recognized brain-enriched protein implicated in neuronal processes.

BASP1 has been associated with Alzheimer's Disease pathology. In post-mortem human AD brain tissue compared to age-matched controls, BASP1 showed consistent down-regulation across subcellular fractions (mean log2 fold-change: −0.72; Chaparral AD proteomics). The analysis employed tandem mass tag proteomics across four subcellular compartments (P2, P3, S2, S3), indicating the protein's reduction was robust across cellular localization states rather than localized to a single fraction.

The selective down-regulation of BASP1 in AD brain suggests a potential loss of protein function or cellular capacity in neurodegeneration, though the mechanistic role of this reduction requires further investigation.