Microtubule-associated protein 1A

# MAP1A (Microtubule-associated protein 1A)

MAP1A is a structural protein that functions as a filamentous cross-bridge between microtubules and other skeletal elements within cells (UniProt: P78559). At 305 kDa and 2803 amino acids in length, it belongs to the microtubule-associated protein family and plays a role in organizing the cytoskeletal architecture necessary for cellular integrity and transport.

The protein is expressed across various tissues where microtubule organization is critical. No specific diseases are currently associated with MAP1A mutations in the UniProt record, though its role in cytoskeletal dynamics suggests potential relevance to processes dependent on neuronal structure and axonal organization.

MAP1A is classified as SFARI category 2 (SFARI Cat 2), indicating it is a gene with some evidence supporting a potential role in autism spectrum disorder, though the evidence is not yet conclusive or replicated to the highest standard.