ATP synthase F(0) complex subunit e, mitochondrial

ATP synthase F(0) complex subunit e (ATP5ME) is a small structural subunit of the mitochondrial ATP synthase complex (Complex V), which catalyzes ATP synthesis coupled to proton translocation across the inner mitochondrial membrane during oxidative phosphorylation (UniProt: P56385). The protein is part of the membrane-embedded F(0) domain and participates in the rotary mechanism that links proton gradient-driven conformational changes to ATP production in the catalytic F(1) head.

ATP5ME is localized to the inner mitochondrial membrane as a component of the respiratory electron transport chain machinery. UniProt records no primary disease associations for this protein, though ATP synthase dysfunction is implicated broadly in mitochondrial and metabolic disorders.

Quantitative proteomics data from human post-mortem Alzheimer's disease brain tissue show ambiguous directionality for ATP5ME across subcellular fractions (mean log2 fold-change: 0.83), indicating variable changes depending on the subcellular compartment analyzed (Chaparral AD proteomics). This ambiguous pattern may reflect differential subcellular redistribution or fraction-specific alterations in ATP synthase assembly or stability in AD pathology, warranting further investigation of mitochondrial energetics in neurodegeneration.