protein
4-trimethylaminobutyraldehyde dehydrogenase
aka TMABA-DH, TMABALDH
Gene
ALDH9A1
Organism
Homo sapiens(9606)
Length
494 aa
Mass
53,802 Da
ALDH9A1 encodes 4-trimethylaminobutyraldehyde dehydrogenase (TMABA-DH), an aldehyde dehydrogenase that catalyzes NAD-dependent oxidation of aldehydes derived from biogenic amines and polyamines. It is notably efficient at converting gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine (UniProt: P49189).
The enzyme participates in polyamine and carnitine metabolism, pathways relevant to cellular energy and membrane integrity. No disease associations are documented in UniProt for ALDH9A1; however, it has been identified in Alzheimer's disease proteomic studies.
ALDH9A1 is upregulated in post-mortem Alzheimer's disease brain tissue compared to age-matched controls, with a mean log2 fold-change of 0.50 across subcellular fractions in TMT-labeled quantitative proteomics (Chaparral AD proteomics). The modest elevation suggests altered aldehyde detoxification or polyamine metabolism in the AD brain, though functional consequences remain to be established.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
not detected
S2
+0.501
S3
not detected
Mean log₂FC across detected fractions: +0.5008 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines
Sources
Last updated 5/8/2026, 6:34:05 AM