protein
Acidic leucine-rich nuclear phosphoprotein 32 family member A
Gene
ANP32A
Organism
Homo sapiens(9606)
Length
249 aa
Mass
28,585 Da
ANP32A (Acidic leucine-rich nuclear phosphoprotein 32 family member A) is a multifunctional regulatory protein encoded by 249 amino acids. It functions in tumor suppression, apoptosis, and cell cycle progression, notably promoting caspase-9-dependent apoptosis and facilitating apoptosome formation (UniProt: P39687). The protein also modulates histone acetylation as part of the INHAT complex, inhibiting EP300/CREBBP histone acetyltransferase activity through histone masking, and participates in mRNA nuclear export regulation and protein phosphatase 2A inhibition.
ANP32A localizes to the nucleus and operates in transcriptional regulation and chromatin-associated processes (UniProt: P39687). The protein exhibits broader roles in viral infections, including essential functions in influenza genome replication through assembly of viral replicase dimers. No intrinsic disease associations are annotated in UniProt for neurological conditions.
ANP32A shows reduced protein abundance in Alzheimer's disease brain tissue relative to age-matched controls (Chaparral AD proteomics), with a mean log2 fold-change of −0.40 across post-mortem human AD brain analyzed via TMT-labeled mass spectrometry. This downregulation may reflect alterations in nuclear protein quality or histone-mediated transcriptional processes implicated in neurodegeneration.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
not detected
P2
-0.396
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3959 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114)
(Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877)
Sources
Last updated 5/8/2026, 6:33:16 AM