protein
ATP synthase F(1) complex subunit gamma, mitochondrial
Gene
ATP5F1C
Organism
Homo sapiens(9606)
Length
298 aa
Mass
32,996 Da
ATP synthase F(1) complex subunit gamma (ATP5F1C) is a mitochondrial protein that forms part of the F(1) head domain of the ATP synthase complex, catalyzing ATP synthesis from ADP using the proton gradient generated by the respiratory chain (UniProt: P36542). The protein participates in the rotary mechanism coupling proton translocation to ATP synthesis in the mitochondrial membrane and is essential for F(1) assembly intermediate formation (UniProt: P36542).
ATP5F1C functions within the mitochondrial oxidative phosphorylation pathway, central to cellular energy metabolism. The protein is involved in ATP production across multiple subcellular compartments (UniProt: P36542).
In Alzheimer's Disease, ATP5F1C is significantly downregulated in post-mortem human brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis of TMT-labeled proteomics across four subcellular fractions revealed a mean log2 fold-change of −0.38, indicating reduced expression of this critical ATP synthase component in AD brain. This downregulation may reflect impaired mitochondrial oxidative phosphorylation capacity in Alzheimer's pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↓ Down in ADP3
-0.379
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: -0.3789 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Subunit gamma, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:37244256). ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel (PubMed:37244256). These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk (PubMed:37244256). During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (Probable). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the central stalk subunit delta, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate (PubMed:29499186)
Sources
Last updated 5/8/2026, 6:27:24 AM