protein
Long-chain-fatty-acid--CoA ligase 1
Gene
ACSL1
Organism
Homo sapiens(9606)
Length
698 aa
Mass
77,943 Da
ACSL1 (Long-chain-fatty-acid–CoA ligase 1) is an enzyme that catalyzes the conversion of long-chain fatty acids to their active acyl-CoA forms, facilitating both cellular lipid synthesis and beta-oxidation for energy metabolism. The protein preferentially activates palmitoleate, oleate, linoleate, and arachidonate (UniProt: P33121).
ACSL1 is widely expressed and plays a key role in lipid homeostasis across tissues. No disease associations are listed in the UniProt entry (UniProt: P33121), though dysregulation of fatty acid metabolism has been implicated in various pathological conditions.
ACSL1 is curated as relevant to Alzheimer's Disease. In post-mortem AD brain tissue, ACSL1 is significantly upregulated compared to age-matched controls (mean log2 fold-change: 0.3818), based on quantitative proteomics across subcellular fractions (P2, P3, S2, S3) using TMT-labeled tandem mass spectrometry (Chaparral AD proteomics). This upregulation may reflect altered lipid metabolism in AD pathology.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
+0.382
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.3818 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity)
Sources
Last updated 5/8/2026, 6:37:38 AM