cAMP-dependent protein kinase type II-beta regulatory subunit

PRKAR2B (cAMP-dependent protein kinase type II-beta regulatory subunit) is a regulatory subunit of cAMP-dependent protein kinase II that mediates intracellular signaling through the cAMP pathway (UniProt: P31323). The protein facilitates membrane association of kinase complexes by binding to anchoring proteins, including MAP2 kinase, thereby organizing cAMP signaling in diverse cellular contexts (UniProt: P31323).

PRKAR2B is expressed across multiple tissues and participates in broader cAMP-dependent signaling cascades that regulate cellular metabolism, gene expression, and neuronal function. No specific monogenic disease associations are annotated in UniProt for this protein.

PRKAR2B shows reduced abundance in Alzheimer's disease brain tissue, with a mean log2 fold-change of −1.077 relative to age-matched controls in post-mortem human brain analyzed by quantitative proteomics (Chaparral AD proteomics). This downregulation across subcellular fractions suggests potential impairment of cAMP signaling in AD pathology, though the functional consequences remain to be characterized.