Glutathione S-transferase Mu 2

Glutathione S-transferase Mu 2 (GSTM2) is a phase II detoxification enzyme that catalyzes the conjugation of reduced glutathione to hydrophobic electrophiles, protecting cells from oxidative stress and xenobiotic damage. It also participates in the formation of hepoxilin regioisomers (UniProt: P28161).

GSTM2 is expressed broadly across tissues where detoxification and metabolic protection are required. No disease associations are documented in the UniProt record for this enzyme.

GSTM2 shows elevated abundance in Alzheimer's Disease brain tissue. According to Chaparral AD proteomics analysis of post-mortem AD brain versus age-matched controls using TMT-labeled DDA proteomics across four subcellular fractions, GSTM2 is significantly upregulated with a mean log2 fold-change of 1.9996. This upregulation may reflect enhanced oxidative stress responses or compensatory glutathione-conjugation activity in AD pathology.