protein
Plasma membrane calcium-transporting ATPase 4
aka PMCA4
Gene
ATP2B4
Organism
Homo sapiens(9606)
Length
1241 aa
Mass
137,920 Da
Plasma membrane calcium-transporting ATPase 4 (PMCA4), encoded by ATP2B4, is a calcium/calmodulin-regulated and magnesium-dependent ATPase that catalyzes the active transport of calcium out of cells (UniProt: P23634). This 1241-amino acid protein maintains cellular calcium homeostasis by coupling ATP hydrolysis to calcium efflux, a process essential for regulating intracellular calcium levels.
PMCA4 is expressed in multiple tissues and plays roles in calcium signaling and cell motility. The protein has been implicated in sperm physiology through its regulation of calcium homeostasis (UniProt: P23634). No baseline disease associations are annotated in UniProt for this entry.
In Alzheimer's disease, PMCA4 shows a modest upregulation in post-mortem AD brain tissue compared to age-matched controls (Chaparral AD proteomics). Analysis of four subcellular fractions (P2, P3, S2, S3) via TMT-labeled tandem mass spectrometry revealed a mean log2 fold-change of 0.1878, indicating slightly elevated protein levels in the AD brain. This subtle elevation may reflect compensatory calcium-handling responses or altered cellular compartmentalization in neurodegeneration.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
not detected
P2
not detected
S2
+0.188
S3
not detected
Mean log₂FC across detected fractions: +0.1878 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Calcium/calmodulin-regulated and magnesium-dependent enzyme that catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell (PubMed:8530416). By regulating sperm cell calcium homeostasis, may play a role in sperm motility (By similarity)
Sources
Last updated 5/8/2026, 6:27:46 AM