protein
Annexin A4
Gene
ANXA4
Organism
Homo sapiens(9606)
Length
319 aa
Mass
35,883 Da
Annexin A4 (ANXA4) is a calcium/phospholipid-binding protein that promotes membrane fusion and participates in exocytotic processes (UniProt: P09525). The 35.9 kDa protein is encoded on the human genome and is widely expressed across tissues where membrane dynamics and vesicular trafficking occur.
ANXA4 has been detected in Alzheimer's Disease brain tissue as part of comprehensive proteomic surveys. In a quantitative analysis of post-mortem AD brain tissue compared to age-matched controls using TMT-labeled tandem mass spectrometry across multiple subcellular fractions, ANXA4 was found to be upregulated with a mean log2 fold-change of 0.55 (Chaparral AD proteomics). This elevation was observed across 2 of 4 examined fractions, suggesting a consistent but modest increase in AD-affected brain regions.
The upregulation of a protein involved in membrane fusion and exocytosis may reflect compensatory or pathological changes in vesicular dynamics associated with neurodegeneration, though the functional significance of this alteration in AD pathology remains to be established.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.549
P2
not detected
S2
+0.552
S3
not detected
Mean log₂FC across detected fractions: +0.5504 (2 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
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Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis
Sources
Last updated 5/8/2026, 6:33:03 AM