protein
Annexin A5
Gene
ANXA5
Organism
Homo sapiens(9606)
Length
320 aa
Mass
35,937 Da
Annexin A5 (ANXA5) is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex involved in the blood coagulation cascade (UniProt: P08758). The protein is a 320-amino acid molecule with a molecular mass of approximately 36 kDa. In UniProt, ANXA5 is associated with recurrent pregnancy loss (RPRGL3), reflecting its role in hemostasis and placental function.
In the context of Alzheimer's Disease, Annexin A5 shows increased abundance in post-mortem AD brain tissue compared to age-matched controls. According to Chaparral AD proteomics data from TMT-labeled quantitative analysis across multiple subcellular fractions (P2, P3, S2, S3), the protein is upregulated with a mean log2 fold-change of 0.84, suggesting a consistent increase across 2 of the examined fractions. This elevation may relate to neuroinflammatory or vascular changes associated with AD neuropathology, though the specific mechanistic contribution remains to be clarified.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+1.160
P2
not detected
S2
+0.521
S3
not detected
Mean log₂FC across detected fractions: +0.8407 (2 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade
Disease associations
Pregnancy loss, recurrent, 3RPRGL3
A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
Sources
Last updated 5/8/2026, 6:32:59 AM