U1 small nuclear ribonucleoprotein 70 kDa

SNRNP70 (U1 small nuclear ribonucleoprotein 70 kDa) is a core component of the spliceosomal U1 snRNP complex, functioning as an essential pre-mRNA splicing factor. The protein binds to the loop I region of U1-snRNA through its RNA recognition motif (RRM) domain and facilitates 5' splice-site recognition and spliceosome assembly (UniProt: P08621).

The protein is expressed in nervous tissue and other organisms as part of the fundamental splicing machinery. No explicit disease associations are documented in the UniProt record for SNRNP70.

In Alzheimer's Disease, SNRNP70 is upregulated in post-mortem AD brain tissue relative to age-matched controls (Chaparral AD proteomics). The protein showed a mean log2 fold-change of +0.56 across the subcellular fractions examined in a TMT-labeled discovery proteomics study. This elevation suggests potential dysregulation of pre-mRNA splicing processes in AD pathology, though the functional consequences remain to be determined.