protein
ATP-dependent translocase ABCB1
Gene
ABCB1
Organism
Homo sapiens(9606)
Length
1280 aa
Mass
141,479 Da
ABCB1 (ATP-dependent translocase ABCB1) is an ATP-driven efflux pump and lipid translocator that catalyzes the energy-dependent movement of drugs and phospholipids across cellular membranes (UniProt: P08183). It mediates the flop of phosphatidylcholine, phosphatidylethanolamine, and other lipids from the cytoplasmic to the exoplasmic leaflet, and functions as the primary determinant of multidrug resistance in cancer cells. The protein is broadly expressed and involved in xenobiotic and lipid homeostasis.
UniProt documents ABCB1 associations with inflammatory bowel disease 13 (IBD13) and acute transient encephalopathy (ENPAT), reflecting its critical role in drug disposition and bloodbrain barrier function. Genetic variants affecting ABCB1 activity influence drug pharmacokinetics across multiple tissues.
ABCB1 is upregulated in Alzheimer's disease brain tissue, with a mean log2 fold-change of +0.68 relative to age-matched controls in post-mortem AD brain (Chaparral AD proteomics). This elevation may reflect increased efflux activity or altered lipid trafficking in AD pathology, though the functional consequence remains to be determined.
Generated from the curated entity record below. May contain errors — verify against source links.
Proteomics Evidence · AD
↑ Up in ADP3
+0.678
P2
not detected
S2
not detected
S3
not detected
Mean log₂FC across detected fractions: +0.6781 (1 of 4 fractions detected)
Human post-mortem AD brain vs age-matched controls, TMT-labeled, 4 subcellular fractions (P2, P3, S2, S3), DDA proteomics.
Related Publications
Browse all →Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease.
Dujardin Simon et al.Nature medicine2020PMID 32572268Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression.
Bai Bing et al.Neuron2020PMID 31926610A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease.
Seyfried Nicholas T et al.Cell systems2017PMID 27989508Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level.
Johnson Erik C B et al.Nature neuroscience2022PMID 35115731Organization and regulation of gene transcription.
Cramer PatrickNature2019PMID 31462772
Function
Translocates drugs and phospholipids across the membrane (PubMed:2897240, PubMed:35970996, PubMed:8898203, PubMed:9038218, PubMed:35507548). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:35970996, PubMed:9038218)
Disease associations
Inflammatory bowel disease 13IBD13
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Encephalopathy, acute transientENPAT
An autosomal recessive neurologic disorder triggered by specific drugs, or acute febrile or afebrile illness. Clinical features include encephalopathy, ataxia, spasticity, pyramidal signs, diplopia, vomiting, and coma. Symptoms fully resolve within few days.
Sources
Last updated 5/8/2026, 6:39:06 AM